We discuss the efficient solution of a large sequence of slowly varying linear systems arising in computations for diffuse optical tomographic imaging. Multimodal breast cancer imaging using coregistered dynamic diffuse optical tomography and digital breast tomosynthesis. Image analysis methods for diffuse optical tomography brian w. Diffuse optical tomography dot using nearinfrared nir light is a promising tool for noninvasive imaging of deep tissue.
Optical mammography is a new application of dot 4 6. Hielscher, diffuse optical tomography with the equation of radiative transfer, international journal for numerical methods in heat and fluid flow 1834, pp. Using diffuse optical tomography with acoustic photonic. Diffuse optical tomography dot is an emerging technology that may solve the above issues. The disadvantage of imaging with light in tissue is the poor resolution in scattering. The results in this paper demonstrate the excellent capability of gcm in working with experimental data measured from optical phantoms mimicking a rat brain with stroke. Diffuse neurofibrillary tangles with calcification. Multispectral, noncontact diffuse optical tomography of. Principles and applications is a longawaited profile of a revolutionary imaging method. Parametric estimation of 3d tubular structures for diffuse. This can be interesting when one is trying to detect, for example, a cancer tumor, which will turn up as an anomaly in the reconstructed model. In this work, we use the radiative transfer equation as forward model which provides an accurate description of the light propagation within biological.
The approach is capable of reconstructing the quantitative optical parameters absorption coefficient and scatter ing coefficient of a soft tissue. Files are available under licenses specified on their description page. Chapter18 diffuse optical tomography of the breast regine choe and arjun g. The most promising clinical translation opportunities are in the differential diagnosis of malignant benign lesions, and in earl. Diffuse optical tomography dot is a promising noninvasive imaging modality and is capable of providing functional characteristics of biological tissue by quantifying optical parameters. The goal of dot is to reconstruct the spatial distribution of optical physiological properties at each point or volume element in the tissue from measurements of fluence rate on the tissue surface. Diffuse optics for tissue monitoring and tomography. Optical tomography is a form of computed tomography that creates a digital volumetric model of an object by reconstructing images made from light transmitted and scattered through an object. The imaging modalities include ballistic imaging, quasiballistic imaging optical coherence tomography, diffusion imaging, and.
Hyperspectral diffuse optical tomography using the. Optode positional calibration in diffuse optical tomography. Keywords inverse problems, diffuse optical tomography, medical and biological imaging, globally. Boas although most current diffuse optical brain imaging systems use only nearestneighbor measurement. Diffuse optical tomography dot allows tomographic 3d, noninvasive reconstructions of tissue optical properties for biomedical applications. Diffuse optical tomography using multi directional. Ambulatory diffuse optical tomography and multimodality.
Dot has many benefits, including its use of nonionizing light and its ability to produce high contrast images, but it also has low resolution. Diffuse optical monitoring of repeated cerebral ischemia. Xu,a johan axelsson, and stefan anderssonengels department of physics, lund university, p. The primary advantages of diffuse optics for monitoring cerebral hemodynamics in the clinic are as follows. Diffuse optical monitoring of repeated cerebral ischemia in mice yu shang,1 lei chen,2 michal toborek,2 and guoqiang yu1, 1. Dot image reconstruction guided by ultrasound us improves the diffused light. The measurements and optical distribution image live in different domain with different dimension 1d 3d, severely illposed. We introduce an hddot imaging system that combines advancements in cap design, ergonomics, and data analysis methods to allow bedside mapping of functional brain.
Publishers pdf, also known as version of record citation for published version harvard. Using a parametric level set method pals our method incorporates the connectedness of vascular structures in breast tissue to reconstruct shape and absorption values from severely limited data sets. Highdensity diffuse optical tomography hddot, a portable imaging modality, potentially enables early continuous and quantitative monitoring of brain function in infants. While the name reflects the original intention to cover image reconstruction of data from the mathematically similar near infra red diffuse optical imaging, to date there has been little development in that area. Diffuse optical tomography and imaging atomic physics. Diffuse optical tomography based on multiple access coding. Development and applications of optical imaging techniques in cancer diagnosis. This technique has been applied for oncology and brain imaging.
Diffuse optical tomography dot has the advantages of being a noninvasive, nonradiation emitting and lowcost biological tissue imaging method, and many recent studies have employed this technology. Because the scattering and absorption of a tumor varies significantly from healthy tissue, a reconstructed spatial representation of these parameters serves as tomographic image of a medium. Hence, the design of an efficient algorithm for image. Functional and molecular imaging center, department of radiology, brigham and womens hospital, boston, ma, usa.
Diffuse optical tomography 14 journal of lasers in medical sciences volume 5 number 1 winter 2014 imaging is related to the accuracy of image reconstruction. Both light and sound have the advantages of being noninvasive, nontoxic, and nonionizing. Correspondingly, diffuse optical tomography dot based on nirsdos has also been developed for 3dimensional 3d imaging of oxygenation distributions in organs or regional tissues arridge and hebden 1997, dehghani et al2009, intes et al 2010, jermyn et al 20, zhang et al 20, eggebrecht et al 2014. Diffuse optical tomography system to image brain activation with improved spatial resolution and validation with functional magnetic resonance imaging danny k. In dot, light is guided by the fiber optics to the surface of the subject e. Bartel, use of penalty terms in gradientbased iterative reconstruction schemes for optical tomography, journal of biomedical.
Severe undersampling is a common problem in dot which leads to image artifacts. Zimmermann,a,b bin deng, a,cbhawana singh,a,c mark martino,a juliette selb, qianqian fang,d. Using our implementation, we simulate a frequency domain diffusive optical tomography system two order of magnitude faster than the standard monte carlo method of light transport in tissues. Diffuse optical tomography dot and fluorescence diffuse optical tomography fdot are noninvasive tools to detect and reconstruct the optical properties inside highly scattering media. The toastmatlab toolbox contains a series of interactive demos that allow to explore specific topics of the forward and inverse problems in diffuse optical tomography. The goal of this work is to provide useful information about arthritic joints using a combination of light and ultrasound.
A comparison of diffuse optical tomography informed by atlas and subjectspeci. Impact of errors in experimental parameters on reconstructed breast images using diffuse optical tomography. Martinos center for biomedical imaging, department of radiology, massachusetts. Diffuse optical tomography using multidirectional sources and detectors takeaki shimokawa,1,4, toshihiro ishii,2,4 yoichiro takahashi, 2 satoru sugawara, masaaki sato,1 and okito yamashita1,3 1atr neural information analysis laboratories, kyoto 6190288, japan 2ricoh institute of future technology, ricoh company ltd.
Paulsen image analysis methods for diffuse optical tomography, journal of biomedical optics 1, 033001 1. In this work, we introduce a compressed sensing cs framework for dot which enables. Diffuse optical imaging is a functional medical imaging modality which takes advantage of the relatively low attenuation of nearinfrared light to probe the internal optical properties of tissue. Boas although diffuse optical tomography is a highly promising technique used to noninvasively image blood. She focused on developing a digital dspbased dynamic imaging system to perform simultaneous dualbreast imaging and subsequently use the imaging system for multiple clinical research projects aimed at. Hemodynamically constrained dynamic diffuse optical. The purpose of this dissertation is to improve image reconstruction in diffuse optical tomography dot, a high contrast imaging modality that uses a near infrared light source. Optical tomography in industry is used as a sensor of thickness and internal structure of.
A large number of measurements is needed in order to minimize these artifacts. Hyperspectral diffuse optical tomography using the reduced. Multispectral, noncontact diffuse optical tomography of healthy human finger joints. Dot is a noninvasive and safe method that can be considered as a functional imaging method 3. Diffuse optical tomography dot has long been investigated as an effective imaging technique for soft tissue imaging, such as breast cancer detection.
Diffuse optical tomography dot has demonstrated huge potential in breast cancer diagnosis and treatment monitoring. Ambulatory nearinfrared spectroscopy anirs and ambulatory diffuse optical tomography adot enable a user to wear a nearinfrared spectroscopy nirs device for noninvasive, continuous monitoring, or imaging of tissue oxygenation and hemodynamics with minimal restrictions on their activities. This forward model produces, for sourcedetector pair, a spatial map of the sensitivity to absorption changes within the head. Nearinfrared diffuse optical tomography nirdot is an emerging technology that offers hemoglobin basedfunctional imaging tumor biomarkers for breast cancer, management. Jan 10, 2011 there are many variants in naming conventions. Nearinfrared light can travel deep in tissue, as a result of the relatively small absorption of water and hemoglobin. The motivation for reconstructing the optical property variation is that it and, in particular, the absorption coefficient. Pdf diffuse optical tomography dot leverages nearinfrared light propagation through in vivo tissue to assess its optical properties and identify. Frontiers brain specificity of diffuse optical imaging. Optode positional calibration in diffuse optical tomography jonathan j. Image analysis methods for diffuse optical tomography. During mollys time as a doctoral student she focused on using diffuse optical tomography imaging for cancer detection and monitoring. The technique is noninvasive and involves no risk to the patient e. The technique samples and reports results in realtime.
Simulation of diffuse optical tomography using comsol. Recycling subspace information for diffuse optical tomography. The diffuse optical tomography dot is a new modality for biomedical imaging. The name was originally an acronym for electrical impedance tomography and diffuse optical reconstruction software. All structured data from the file and property namespaces is available under the creative commons cc0 license. Center for biomedical engineering, university of kentucky. Sparsity regularization in diffuse optical tomography by. Diffuse optical tomography and imaging can be performed with different experimental approaches. Chromophore concentrations and diffusion amplitude are recovered using a linearized born approximation model and employing data from over 100 wavelengths. Yodh department of physics and astronomy, university of pennsylvania, philadelphia, pa 19104, usa. A parametric level set method pals is implemented for image reconstruction for hyperspectral diffuse optical tomography dot. Paulsen dartmouth college thayer school of engineering hanover, new hampshire 03755 abstract. We also discuss diffuse correlation spectroscopy dcs, a technique whereby temporal correlation functions of diffusing light are transported through tissue.
It has been observed that malignant and normal tissues differ in blood flow f and oxygen consumption oc. Download acrobat pdf file 70kb supplementary material. Models and algorithms for diffuse optical tomographic system. Introduction t he prostate gland may not be considered as a lifesustainingorgan,butprostatecancerpcaclaimsthelives of about 28000 american men every year 1. In recent years hyperspectral dot hydot has been proposed, in an effort to improve that resolution.
Dec 03, 2012 3 simon r arridge and john c schotland optical tomography. The diffuse optical tomography dot is a new modality for biomedical imaging 1 3. The approach is capable of reconstructing the quantitative optical parameters absorption coefficient and scattering coefficient of a soft tissue. Clinical applications of nearinfrared diffuse correlation. Diffuse optical tomography dot and imaging doi are noninvasive techniques that utilize light in the near infrared spectral region to measure the optical properties of physiological tissue. Lifetime risks for a diagnosis of pca and as the cause of death for american.
The theoretical basis for nearinfrared or diffuse optical spectroscopy nirs or dos, respectively is developed, and the basic elements of diffuse optical tomography dot are outlined. Noninvasive monitoring of liver metastasis development via. Simulation study eleonora vidolova department of electrical and computer engineering master of science di. When used to create 3d volumetric models of the imaged material doi is referred to as diffuse optical tomography, whereas 2d imaging methods are classified as. Image reconstruction for diffuse optical tomography based. Jonathan lavaud 1,2, maxime henry 1,2, pascal gayet 3, arnold fertin 4, julien vollaire 1,2, yves usson 4, jeanluc coll 1,2, veronique josserand 1,2. Three major analytical tools in imaging science are summarized and demonstrated relative to optical imaging in. Yalavarthy thayer school of engineering dartmouth college hanover, new hampshire september 2007 examining committee. Fluorescence diffuse optical tomography using upconverting. Diffuse optical tomography is a novel molecular imaging technology for small animal studies. We explore the use of diffuse optical tomography dot for the recovery of 3d tubular shapes representing vascular structures in breast tissue. The optical properties are affected by parameters related to physiology such as the concentrations of oxy and deoxyhemoglobin. The technique uses a combination of highdensitymeasurements,forwardmodeling,andanimagereconstruction. It is a computerassisted method for the threedimensional reconstruction of images showing changes in cerebral hemodynamics.
After the fundamentals of photon transport in biological tissues are established, various optical imaging techniques for biological tissues are covered. Diffuse optical imaging doi is a method of imaging using nearinfrared spectroscopy nirs or fluorescencebased methods. One often employed setup uses timeresolved excitation and detection schemes, in which multiple picosecond diode laser pulses are introduced into the tissue under study. Noninvasive monitoring of liver metastasis development via combined multispectral photoacoustic imaging and fluorescence diffuse optical tomography. Functional imaging of the developing brain at the bedside. Diffuse optical tomography dot is a noninvasive imaging technique to detect the presence of a tumor or other anomalies in human tissues. Diffuse optical tomography dot is an imaging modality with potential use in breast cancer detection, diagnosis and monitoring, brain imaging, and small animal imaging. In the forward model yax, photon migration is simulated in a segmented head obtained from an anatomical mri. Original article ultrasonography guided diffuse optical tomography for noninvasive monitoring of breast cancer during neoadjuvant chemotherapy yan dong 1, jinwei qiang, cai chang2, shichong zhou2 1department of radiology, jinshan hospital, fudan university, shanghai, china. Fluorescence diffuse optical tomography using upconverting nanoparticles can t. Multimodal molecular diffuse optical tomography system. Gregg nm, white br, zeff bw, berger aj and culver jp 2010 brain specificity of diffuse optical imaging. Submitted to the faculty of the graduate college of the. Development and applications of optical imaging techniques in.
A soft deformable tissueequivalent phantom for diffuse. Written by an authority involved in the field since its nascent stages, diffuse optical tomography. Acknowledgements when i was at a crossroads in deciding the graduate school, i ran across the physics today article written by arjun yodh and britton chance bc. Pages in category optical imaging the following 17 pages are in this category, out of 17 total. Diffuse optical tomography system to image brain activation. Optical mammography is a new application of dot dot is a noninvasive and safe method that can be considered as a functional imaging method. Diffuse optical tomography dot provides spatial distributions of intrinsic tissue optical properties or molecular contrast agents through modelbased. Optical tomography is used mostly in medical imaging research. Multimodal breast cancer imaging using coregistered.
Reconstructions for continuouswave diffuse optical. Original article ultrasonography guided diffuse optical. Anatomical atlasguided diffuse optical tomography of. Multisubject and multitask experimental validation of. Diffuse optical tomography dot is a noninvasive, nonionizing, and inexpensive imaging technique that uses nearinfrared light to probe tissue optical properties. Electrical impedance and diffuse optical tomography. Osa compressed sensing in diffuse optical tomography. Most known reconstruction methods use the diffusion equation da as forward model, although the validation of da breaks down in certain situations. Diffuse optical tomography and microendoscopy authors. Infrared diffuse optical tomography athesis submitted to the faculty in partial ful. Light has the advantage of generating a spectroscopic view of a specific volume of soft tissue.
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